Cdk5 keeps memory on Trk
نویسندگان
چکیده
منابع مشابه
Chronic exercise keeps working memory and inhibitory capacities fit
Padilla et al. (2013) recently showed that chronic aerobic exercise in young adults is associated with better inhibitory control as measured by the strategic Stop Signal Task (SST). The aim of the current study was to explore whether better inhibitory abilities, associated with high levels of physical fitness, were also associated with higher working memory capacity (WMC) in young healthy adult...
متن کاملCdk5 on the brain.
Mammalian brains are highly compartmentalized into groups of functionally specialized neurons. Cell migration and neurite outgrowth must be tightly orchestrated to achieve this level of organization. A small serine/threonine kinase that shows homology to cyclin-dependent kinases (Cdks) has emerged as an important regulator of neuronal migration. Cdk5, unlike other Cdks, is not regulated by cycl...
متن کاملOn Trk for Retrograde Signaling
Target-derived neurotrophins like nerve growth factor (NGF) mediate biological effects by binding to and activating Trk neurotrophin receptors at nerve terminals. The activated Trk receptors then stimulate local effects at nerve terminals, and retrograde effects at neuronal cell bodies that often reside at considerable distances from the terminals. However, the nature of the retrograde signal h...
متن کاملLearning and Memory: While You Rest, Your Brain Keeps Working
A recent study shows that brain activity recorded while the human subject is at 'rest' is significantly affected by a prior learning episode. These results suggest that understanding resting brain activity may be critical to understanding how humans learn from experience.
متن کاملMemory Enhancement by Targeting Cdk5 Regulation of NR2B
UNLABELLED Many psychiatric and neurological disorders are characterized by learning and memory deficits, for which cognitive enhancement is considered a valid treatment strategy. The N-methyl-D-aspartate receptor (NMDAR) is a prime target for the development of cognitive enhancers because of its fundamental role in learning and memory. In particular, the NMDAR subunit NR2B improves synaptic pl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2012
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn1112-1474